Description
Form: Lyophilized powder vial | Purity: ≥99% | Storage: Refrigerate
What It Is
MOTS-c is a mitochondrial-derived peptide encoded in the mitochondrial genome. It was discovered in 2015 and is considered one of the most exciting longevity compounds identified in recent years. It acts as a metabolic regulator, communicating between mitochondria and the nucleus to optimize cellular energy use.
What It Does
MOTS-c improves insulin sensitivity, increases fat burning, enhances exercise capacity, reduces obesity, and extends lifespan in animal models. It activates AMPK, a master metabolic switch that promotes fat oxidation and improves cellular energy efficiency. It also has anti inflammatory and anti aging effects.
How It Works
MOTS-c travels from mitochondria to the nucleus where it regulates gene expression related to metabolism and stress response. It activates AMPK and inhibits the folate cycle, which shifts cellular metabolism toward fat burning and away from fat storage. It also reduces reactive oxygen species and mitochondrial stress.
Who Benefits Most
People with insulin resistance, metabolic syndrome, or obesity. Athletes looking to improve endurance and fat oxidation. Anyone interested in longevity and mitochondrial health. People with chronic fatigue or poor cellular energy production.
Cautions
Well tolerated in research models. Limited long term human safety data available. Use under practitioner supervision. Not recommended during pregnancy.
Pairs Well With
NAD+ for comprehensive mitochondrial and longevity support. Epitalon for additional anti aging effects. Retatrutide for comprehensive metabolic optimization.
Quality and Sourcing
Every Smart Stack batch is tested for purity, sterility, potency, and identity. Certificates of Analysis are available on request.
- HPLC purity testing
- LC-MS identity confirmation
- Sterility and endotoxin testing
- Heavy metals screening
- Purity: greater than or equal to 99%
For research use only. Not for human consumption. Not for resale. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.














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